CXCR2 and deep vein thrombosis: Furthermore, in a mouse model, P-selectin in neutrophils activated the synergistic effects of PSGL-1 and C-X-C motif chemokine receptor 2 (CXCR2), thereby promoting neutrophil adhesion in blood flow-restricted veins, stimulating the release of NETs, and ultimately leading to deep vein thrombosis (123, 124).