Although the cause of PD is not fully understood, a large amount of evidence indicates that neuronal degeneration is always accompanied by neuroinflammation (2–5), presented by reactive morphology of microglia and astrocytes, infiltration of monocytes/macrophages, and increased cytokine levels such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in cerebrospinal fluid (CSF) and blood (6–10). This evidence concerns the gene TNF and Parkinson disease.