In addition, Urh et al. (11) bioinformatically analyzed normal mucosal, colorectal adenoma, and colorectal cancer differential genes from GEO as well as The Cancer Genome Atlas (TCGA) databases and found that tumor stem cell-related genes (ANLN, CDK1, ECT2, and TNC) were associated with colorectal carcinogenesis, while ANLN and PDGFD genes were associated with the progression of colorectal cancer, but the mechanism of action of these genes with the development of colorectal cancer still needs further study and validation. The gene discussed is ANLN; the disease is colorectal adenoma.