APOE and Alzheimer disease: The prevalence of CVD has also been shown to increase with age (Yazdanyar and Newman, 2009; North and Sinclair, 2012), and individuals with CVD are at a higher risk for AD especially if they carry the APOE4 allele (Stampfer, 2006; Eriksson et al., 2010; de Bruijn and Ikram, 2014).