Stratifying by sex and age (Table 5), our results showed that in older age groups, APOE ε4 men carriers had a higher AD risk than women (OR = 2.64, 95% CI = 1.51–4.60 in men; OR = 1.90, 95% CI = 1.26–2.86 in women). This evidence concerns the gene APOE and Alzheimer disease.