When considering both sex and age, the risk of AD was higher among older men carrying APOE ε4 (OR = 2.64, 95% CI = 1.51–4.60 in men; OR = 1.90, 95% CI = 1.26–2.86 in women), while women carrying APOE ε4 appeared to have an increased risk at a younger age (OR = 3.29, 95% CI = 2.20–4.93 in women; OR = 2.91, 95% CI = 1.40–6.05 in men). Here, APOE is linked to Alzheimer disease.