A possible explanation for the higher AD risk in APOE ε4 carrier men at an older age is that the age-adjusted period of prevalence for cardiovascular disease (CVD) related to APOE genotype is higher in men than in women (18.6% in the ε4 group for men and 9.9% for ε4 women) (Lahoz et al., 2001). The gene discussed is APOE; the disease is Alzheimer disease.