APOE and Alzheimer disease: Apolipoprotein E ε4 carrier women (OR = 2.38, CI = 1.81–3.14) and men (OR = 2.64, CI = 1.75–3.98) did not show a significant difference in AD risk (APOE-sex interaction P-value = 0.46); however, APOE ε4 homozygous women appear to have an increased risk compared with homozygous men, but the number of ε4 homozygous cases is too small to demonstrate statistical differences between sexes (Table 3).