LRRK2 and Parkinson disease: Overexpression of either wild-type LRRK2 or LRRK2G2019S leads to increased ROS production and reduced mitochondrial function in mice, fruit flies, iPSC cell cultures and PD patients (Mortiboys et al., 2010; Cooper et al., 2012; Ng et al., 2012; Yue et al., 2015).