TARDBP and amyotrophic lateral sclerosis: ALS, the most common form of motor neurone disease (MND), is characterized by a progressive, paralysis-causing loss of motor neurones in the brain and spinal cord (Hulisz, 2018) and the presence of inclusions containing TDP-43, a protein that becomes pathological when hyper-phosphorylated or hyper-ubiquinated (Lillo and Hodges, 2009).