Several ALS-associated genes are functionally implicated in autophagy, including SQSTM1, C9orf72, Ubiquilin-2, and VAPB (Mao et al., 2019; Şentürk et al., 2019; Wu et al., 2020; Cozzi and Ferrari, 2022). Here, SQSTM1 is linked to amyotrophic lateral sclerosis.