In addition, we considered whether the NLRP3 inflammasome had a role, since although NLRP3 is mainly expressed in myeloid cells, some studies have shown that NLRP3 inflammasome is activated in respiratory epithelial cells following viral infection,20 and also that cytosolic poly(I:C) activated NLRP3 in macrophages.19 The gene discussed is NLRP3; the disease is viral infectious disease.