ALB and acute kidney injury: According to ICA guidelines, HRS is diagnosed in a patient with cirrhosis and ascites who has stage ≥2 AKI and lack of improvement despite the withdrawal of diuretics or trial of treatment with albumin for plasma volume expansion (1 g/kg per day with a maximum of 100 g/day) for a total of 48 hours, and has no evidence of other etiologies causing kidney injury (i.e., absence of shock, no current or recent use of nephrotoxic drugs, no macroscopic signs of structural kidney injury, such as the presence of proteinuria, microhematuria, or abnormal findings on renal ultrasonography) [21].