PLG and hyperinsulinemic hypoglycemia, familial, 4: This is alongside urinary losses of negatively charged anticoagulant proteins such as antithrombin, protein C and S leading to reduction in their levels, and impaired fibrinolytic activity (decreased plasminogen levels, elevated plasminogen activator inhibitor-1 levels or albumin deficiency-related impairment of the interaction of plasminogen-fibrin).