SPG11 and hereditary spastic paraplegia: Mutations in the endosomal clathrin adaptor complex AP5, a protein comprising a central α‐solenoid with two long flexible IDRs harboring protein–protein interacting appendage domains, and the associated large IDPs SPG11/Spatacsin (Stevanin et al, 2007) and ZFYVE26/Spastizin (Vantaggiato et al, 2019) cause autosomal‐recessive spastic paraplegia/paraparesis (HSP), a movement disorder that manifests in progressive loss of lower limb movement control (Table 1).