Our study indicated that aberrantly circPRKAR1B overexpression induced by METTL3‐mediated m6A modification impaired autophagy and pyroptosis activation by interacting with the RBP SPTBN1, aggravating Crohn's colitis (Figure 8).The RNA‐seq and bioinformatic analysis progress have detected multiple circRNAs in many diseases and have received extensive attention.37 The gene discussed is SPTBN1; the disease is Crohn's colitis.