Univariate analysis indicated physical status (PS) score (p = 0.033), PD-L1 expression (p = 0.021), COVID-19 vaccination (p = 0.002), albumin (p < 0.001), fibrinogen (p < 0.001) checked before ICIs treatment were independent prognostic factors for PFS in NSCLC patients with ICIs treatment. The gene discussed is CD274; the disease is COVID-19.