Four of 6 cases with > 5 SNV + Indel/Mb and germline variations in MLH1, MSH2, MSH6, PMS2, POLE or POLD1 belonged to Myeloid Predominant, suggesting higher levels of immune infiltration in patients with biallelic Mismatch Repair Deficiency (bMMRD) syndrome. This evidence concerns the gene POLE and mismatch repair cancer syndrome 1.