Thus identification of ALT depends on a tumor displaying multiple of ALT’s characteristics such as (i) absence of telomerase activity, (ii) presence of telomeres of substantial (> 50 kb) and heterogeneous length (< 8 kb and > 50 kb), (iii) elevated levels of telomere sister chromatid exchange, (iv) extra-chromosomal telomeric repeats or C-circles, (v) telomere dysfunction-induced foci (TIFs) [58, 61]. The gene discussed is GPT; the disease is neoplasm.