IFNG and neoplasm: However, our study also has some limitations in that we only clearly proved that ILC1s could promote the induction of M1-like macrophages by secreting IFN-γ in vitro, and our in vivo results do not show that ILC1s directly affect tumor-infiltrating macrophages by secreting IFN-γ to perform an antitumor function in the tumor microenvironment.