IFN-γ and lipopolysaccharide (LPS) promote macrophage polarization toward the classically activated antitumor M1-like phenotype, while IL-4 and IL-13 result in macrophage polarization toward the M2-like phenotype and can be used as immunotherapeutic targets in macrophage-based tumor immunotherapy [18–20]. The gene discussed is IFNG; the disease is neoplasm.