As indicated in Fig. 4F and G, organoid #Pv24 was the most sensitive organoid to GSK126 treatment with the lowest UTX expression, while organoid #Pv11 was the most resistant organoid to GSK126 treatment with the highest UTX expression, indicating an intrinsic reverse correlation between UTX expression and sensitivity to EZH2 inhibitor in human CRC. The gene discussed is EZH2; the disease is colorectal carcinoma.