The major findings were as below: (1) platelet reactivity during clopidogrel treatment was higher in patients with diabetes than those without diabetes, which was related with insulin treatment and the severity of DM (HbA1c level); (2) HPR enhanced the risks of MACCE and all-cause death, which association appeared significant only in diabetic patients; (3) the risk of major bleeding was not associated with HPR phenotype; and (4) prognostic implication of diabetic status and HPR phenotype appeared similar, and its association showed the synergistic effect on MACCE rate. The gene discussed is INS; the disease is diabetes mellitus.