In tumor-associated aged neutrophils (CXCR4+CD62Llow), induced by tumor-derived Nicotinamide Phosphoribosyl transferase (NAMPT), are capable of forming two types of NETs: mitochondria-dependent vital NETs, where SIRT1 induces the opening of mitochondrial permeability transition pore channels to release mitochondrial DNA, and traditional Cit-Histone H3-dependent fatal-NETs [136, 137]. The gene discussed is CIT; the disease is neoplasm.