The initial focus was on confirming the anti-tumor function, which was believed to be achieved through various mechanisms, including direct killing via the production of reactive oxygen species (ROS) whose killing function is dependent on tumor cell expression of TRPM2[18, 73] and reactive nitrogen species (RNS) where MET is necessary, as well as antibody-dependent cytotoxicity (a newly discovered mechanism called “trogoptosis“ [74]). Here, TRPM2 is linked to neoplasm.