Similarly, we showed that the meQTL of PFKFB2 had SNPs associated with HbA1c, eGFR, and creatinine, and at the same time the gene had associations with carbohydrates, lipids, phenylalanine and alanine that are involved in both T2D [17, 18] and kidney function [62, 63], suggesting that the metabolic perturbations could be an end effect of the meQTL. This evidence concerns the gene PFKFB2 and type 2 diabetes mellitus.