GWAS associations of meQTL SNPs with T2D-related traits such as HbA1c (HK1 and PFKFB2), BMI (EFEMP2, CFL1), eGFR and creatinine (PFKFB2), diabetic nephropathy, urate levels (EFEMP2), bilirubin (HK1), and white blood cell counts (DOCK10, EFEMP2, SLC2A1, CFL1, PFKFB2) [51, 60, 61], further emphasize the involvement of the meQTL genes in the pathogenesis of T2D. Here, PFKFB2 is linked to type 2 diabetes mellitus.