POR and diabetes mellitus: Moreover, since reproductive and fertility complications may arise from diabetes [66], it is interesting to note that STYXL1, the meQTL gene of the cg01676795 (POR) is known to be associated with seminal vesicle tumor and male reproductive organ benign neoplasm [67], that may help in understanding the link of POR to a network of sphingosines and ceramides which play a role in forming steroids [68].