One example is the alanine subnetwork that links PFKFB2 and TXNIP to the urea cycle and to amino acids, where amino acids were associated with triglycerides (alanine association with triglycerides: discovery p-value of p = 6.4 × 10–12, replication p-value of p = 9.3 × 10–13) and where both urea cycle and alanine have been associated with kidney failure [64]. The gene discussed is TXNIP; the disease is kidney failure.