The most significantly-associated T2D methylated gene, thioredoxin-interacting protein (TXNIP), plays a role in insulin sensitivity, is a tumor suppressor that is upregulated in diabetes, is induced when glucose levels are elevated, and its deficiency improves glucose tolerance and increases insulin sensitivity in high fat diet-induced obesity [34, 39]. Here, TXNIP is linked to obesity due to melanocortin 4 receptor deficiency.