Finally, the high expression of RNASET2 was verified using the renal cell carcinoma cell lines (A498, 786-O and OSRC-2) and HK-2, as well as 8 pairs of ccRCC tissues and adjacent normal tissues from our medical center (Fig. 1, I and J). This evidence concerns the gene RNASET2 and nonpapillary renal cell carcinoma.