There are many mutated genes have been reported to be associated with clear cell renal cell carcinoma, including von Hippel Lindau(VHL) [44], Polybromo 1 (PBRM1) [45], BRCA associated protein 1 (BAP1) [46] and SET domain containing 2 (SETD2) [47]. The gene discussed is VHL; the disease is clear cell renal carcinoma.