EGF and neoplasm: The cytokines produced by these cells play a central role in shaping the tumor microenvironment, thereby driving immune-mediated anti-tumor or pro-tumor activity in the tumor microenvironment [35]. Overall, MYL1 promotes metastasis and correlates with tumor immune infiltration in HNSCC, which may explain why MYL1 is down-regulated but its relative high expression level is associated with a poor prognosis in HNSCC, and provides new insights into the mechanisms of HNSCC.  These effects of MYL1 may be related to the EGF/EGFR signaling pathway.