In a subsequent prospective multicenter study examining 68Ga-PSMA PET in 2005 patients with recurrent PCa, the overall per-patient scan positivity rate was 78%, with increasing positivity rates at higher PSA concentration subgroups: <0.25 ng/ml, 44.8%; 0.25-0.49 ng/ml, 50.5%; 0.5–0.99 ng/ml, 69.2%; 1.00-1.99 ng/ml, 78.1%; and >2.00 ng/ml, 95% (95% CI 92–97) [45]. This evidence concerns the gene KLK3 and posterior cortical atrophy.