By contrast, downregulation of CYP3A5 mRNA expression and predominant scIC transcriptomic profiles were associated with the emergence of GATA6+CYP3A+KRT17+, GATA6–CYP3A+KRT17+, GATA6–CYP3A–KRT17+ and GATA6+CYP3A–KRT17+ cells in post-CTX samples (Extended Data Fig. 5a). This evidence concerns the gene CYP3A4 and cerebrotendinous xanthomatosis.