To address the question if this assumption is valid, we investigated a pooled cohort of 936 NPM1-mutated AML patients who were treated in previously reported multicenter trials of the Study Alliance Leukemia (SAL; AML96 [NCT00180115], AML2003 [NCT00180102], AML60+ [NCT00180167], SORAML [NCT00893373]) and the AML Cooperative Group (AMLCG-1999 [NCT00266136], AMLCG2008 [NCT01382147]). This evidence concerns the gene NPM1 and acute myeloid leukemia.