SHBG and Insulin resistance: Cluster analysis of the RG signals with 45 related phenotypes identified three separate clusters (Fig. 1a, Supplementary Table 23 and Extended Data Figs. 6 and 7), including ‘metabolic syndrome’ cluster 1, with 28 loci also leading to higher waist-to-hip ratio, blood pressure, plasma triglycerides, insulin resistance (HOMA-IR) and coronary artery disease risk, as well as lower sex hormone binding globulin levels in both sexes and testosterone in males.