We bioinformatically estimated TL from whole exome sequencing data, generated from ROSMAP DLPFC brain samples, and leveraged the existing mtDNAcn and epigenetic cortical clock estimates of the same samples34,36 to understand the effect of multiple genomic signatures of aging on clinical and pathologic features of AD, other neurodegenerative diseases, and cerebrovascular disease (CVD). The gene discussed is CLOCK; the disease is neurodegenerative disease.