CLOCK and Alzheimer disease: Interestingly, cortical clock age was positively associated with all four pathologic measures of AD; NIA-Reagan diagnosis (OR = 1.19, p = 0.0029), global AD pathology (beta = 0.03, p = 0.0003), amyloid beta (beta = 0.06, p = 0.0047), and tau tangles (beta = 0.07, p = 0.0183).