Similar results were also observed in glioblastoma,39 oral carcinomas40 and leukaemia.61 Next, we further revealed that the PI3K-AKT pathway was activated in C4 cells and CD36+ tumour cells, and inhibition of PI3K-AKT signalling suppressed PA tumorosphere formation and organoid growth. The gene discussed is AKT1; the disease is leukemia.