The incidence of lymphoma development in B-TRAF2/3-DKO mice is apparently lower than what reported in B-TRAF3-KO mice, an observation might be explained as follows: (1) The criteria to define B cell lymphomas may be different between current study and previous reports; (2) Environmental factors (e.g., microbiome) may affect B cell homeostasis and oncogenesis in B-TRAF3-KO or B-TRAF2/3-DKO mice since studies were carried out in different animal facilities, which may warrant future studies. This evidence concerns the gene TRAF3 and B-cell non-Hodgkin lymphoma.