During S phase, WEE1 is implicated in the maintenance of genome integrity through CDK2-regulated replication initiation and Mus81-Eme1 endonuclease mediated processing of stalled replication forks.183,184 In light of its sophisticated functions, WEE1 depletion or inhibition render cancer cells die of replicative or mitotic catastrophe, and hypersensitive to chemotherapy or radiation as expected.185,186. The gene discussed is WEE1; the disease is cancer.