Y220C inactivates p53 by destabilization of p53 DNA binding domain by around 4 kcal/mol.305 Of the most importance, Y220C left a cavity on p53 surface which can be bound by small molecules.306 A set of binders have been developed,307–309 which promoted p53Y220C stability, restored conformation and transcription regulation, and selectively led to TP53Y220C mutant tumor cell apoptosis. The gene discussed is TP53; the disease is neoplasm.