PARG and cancer: As dynamic and stringent regulation of PARylation is indispensable for optimal DDR, PARG is also validated as a potential DDR target for cancer treatment.334 PARG inhibition was shown to be hypersensitive in cells with replication vulnerability, leading to failure to restart stalled replication fork and persistent replication stress.335 Although a set of PARG inhibitors have been reported, none of them reaches clinic to our knowledge.