In high-grade glioma (Figure 5A), EIF4E1B and NUDT11 acted as protective factors for OS, while the remaining factors posed a risk for Spatterwares, we conducted the LASSO regression analysis and discovered 13 genes that were incorporated into the ultimate prognostic model (AGO2, CYFIP1, DCP2, EIF4E1B, EIF4G3, GEMIN5, METTL1, NCBP1, NUDT11, NUDT16, SNUPN, WDR4, LARP1, (Figure 5B, 5C, Supplementary Table 2). The gene discussed is AGO2; the disease is central nervous system cancer.