High-grade glioma exhibited high expression levels of twelve genes involved in m7G regulation (METTL1, WDR4, NSUN2, DCPS, NUDT4B, CYFIP1, NCBP1, NCBP2, EIF3D, EIF4A1, LSM1, and SNUPN), while eight genes (NUDT10, NUDT11, NUDT3, EIF4E1B, EIF4E3, LARP1, EIF4G3, and NCBP2L) showed low expression levels. Here, NSUN2 is linked to central nervous system cancer.