High-grade glioma exhibited high expression levels of twelve genes involved in m7G regulation (METTL1, WDR4, NSUN2, DCPS, NUDT4B, CYFIP1, NCBP1, NCBP2, EIF3D, EIF4A1, LSM1, and SNUPN), while eight genes (NUDT10, NUDT11, NUDT3, EIF4E1B, EIF4E3, LARP1, EIF4G3, and NCBP2L) showed low expression levels. The gene discussed is NCBP2L; the disease is central nervous system cancer.