High-grade glioma exhibited high expression levels of twelve genes involved in m7G regulation (METTL1, WDR4, NSUN2, DCPS, NUDT4B, CYFIP1, NCBP1, NCBP2, EIF3D, EIF4A1, LSM1, and SNUPN), while eight genes (NUDT10, NUDT11, NUDT3, EIF4E1B, EIF4E3, LARP1, EIF4G3, and NCBP2L) showed low expression levels. This evidence concerns the gene NUDT4B and central nervous system cancer.