Fucoxanthinol, the deacetylated form of fucoxanthin, an algae-originating carotenoid, generated in the gastrointestinal tract (5 μM for 2 d), modulated the human pancreatic PANC-1 cancer cell transcriptome in pathways regarding the cell cycle, integrin, AKT, MAPK, NRF2, adipogenesis, transforming growth factor beta (TGF-β), signal transducer and activator of transcription (STAT), or WNT signals [100, 101]. The gene discussed is TGFB1; the disease is cancer.