MAGEB2 and nonpapillary renal cell carcinoma: For example, MAGE-B2, which was the most upregulated gene in the SBS1-high ccRCC cohort, promotes stress tolerance, giving a growth advantage to cancer cells, and its high expression has been implicated in tumour growth and progression in various cancers in vitro but has not been studied previously in RCCs [35], [36], [37], [38].