S100A12 and periodontitis: S100-A12 is known to bind to a receptor for advanced glycationend-products (RAGE), whose activation leads to proinflammatory effects.21 In humans, S100-A12 is implicated in many diseases,including coronary heart disease,23 periodontitis,24 as well as lung disease, including pulmonarytuberculosis.25 S100-A12 has been previouslydetected in bovine milk and described as a marker of subclinical mastitis.26 It has also been reported in cows infected with Mycobacterium avium ssp.