PER1 and allergic respiratory disease: Previously, we developed a triple-aeroallergen vaccine in pNZ8149/L. lactis NZ3900 against the top three major indoor aeroallergens, Der p 2 (mite), Per a 2 (roach), and Cla c 14 (mold), and proved its efficacy and safety for prevention of respiratory allergy in a mouse model [37].