Given that PARG suppression was indicated as one of the mechanisms of PARPi resistance in BRCA2-deficient cancer cells,47 we additionally explored the effect of TARG1 loss on PARGi sensitivity in BRCA2-deficient ovarian cancer PEO1 cells and observed a similar sensitivity phenotype (Figures 2B and S2B). Here, OARD1 is linked to ovarian carcinoma.