Therefore, despite not exhibiting the FMF phenotype, the patients’ positive response to colchicine treatment expands our understanding of colchicine’s role in FMF solely caused by pyrin; furthermore, based on this study demonstrating the influence of the E583 site on pyrin’s autoinhibition, the patient still responded to colchicine treatment, which, akin to previous research, suggests that colchicine may play a role in downstream steps of pyrin inflammasome activation. The gene discussed is MEFV; the disease is familial Mediterranean fever.