To examine the impact of inflammatory demyelination on the neuronal transcriptome, we induced experimental autoimmune encephalomyelitis (EAE) with a myelin oligodendrocyte glycoprotein peptide (MOG35–55) in Syn.Cre × Rpl22 mice and extracted neuronal RNA from the cortex at the peak of disease (18 days after induction). The gene discussed is MOG; the disease is experimental autoimmune encephalomyelitis.