SLC12A3 and Central diabetes insipidus: Here, we avoided the stress of prolonged consumption of an extremely high-potassium diet, which can increase BP in mice (54, 66, 67) when potassium is too high or induce diabetes insipidus when it is too low (68), and measured BP over a titration of increased dietary potassium when NCC became acutely dephosphorylated.