AGO1 and viral infectious disease: For instance, tombusvirus infection enhances mRNA level of AGO1 to resist virus infection, however, tombusvirus p19, as a RNA-silencing suppressor, mediates the induction of the miR168 expression to down-regulate endogenous AGO1 mRNA level and inhibit the translational capacity of AGO1 mRNA (Varallyay et al., 2010).