In esophageal squamous cell carcinoma (ESCC), SIRT7 deacetylates the promoter of E74 like ETS transcription factor 3 (ELF3), rendering it no longer able to suppress miR-144-3p, a posttranscriptional suppressor of zinc finger E-box binding homeobox 1/2 (ZEB1/2) EMT markers. The gene discussed is SIRT7; the disease is esophageal squamous cell carcinoma.