Later studies report that SIRT7 has similar roles in oral squamous cell carcinoma (OSCC): it is successively downregulated in OSCC and inhibits EMT in vitro and lung metastasis in vivo (142); miR-770 promotes OSCC metastasis by targeting SIRT7 and inhibiting the downregulation of SMAD4 signaling (152). Here, SIRT7 is linked to oral cavity squamous cell carcinoma.