Furthermore, the results from Westernblot analysis indicate a therapeutic effect of melatonin treatmentto regulate mitophagy-related proteins, showing a normalized expressionlevel of Parkin, PINK1, and LC3 in the brain of METH-WD/mel and anincreasing trend of synaptophysin expression in METH-WD/mel and melmice when compared to METH-WD and control groups. The gene discussed is PINK1; the disease is Wilson disease.