TEAD1 was corroborated as an HPV8 E6 interaction partner via co-immunoprecipitation using either HCT116 colon cancer epithelial cells transiently transfected with FLAG/HA-tagged HPV8 E6 (Fig. 2A) or telomerase immortalized normal human oral keratinocytes (NOKs) with stable expression of FLAG/HA-tagged HPV8 E6 (Fig. 2B). Here, TEAD1 is linked to malignant colon neoplasm.