In sum, the CCNT1.C261Y modification enforced a state of viral latency in human T cells consistent with the inhibition of HIV-1 Tat and severely restricted the potential for viral reactivation in the presence of LRAs, collectively achieving the defining characteristics of a “block-and-lock” scenario even at early time points post-infection and in the absence of suppressive agents. The gene discussed is CCNT1; the disease is infection.