Analysis of RNA-sequencing data of D. discoideum during M. marinum infection (14, 15) revealed a possible role for ER-dependent repair: Genes encoding the homologs of the PI4P phosphatase Sac1 and several PI4Ks (pi4k and pikD) were upregulated at later infection stages when M. marinum inflicts major membrane damage (Fig. 1A). The gene discussed is SACM1L; the disease is infection.