Myeloid‐associated (M‐CSF, GM‐CSF, and MIF) or fibroblast growth factor (FGF‐2, FGF‐7), vascularization (VEGF‐C, VCAM‐1), or extra‐cellular matrix components (MMP‐1, MMP‐9, and collagen, type 1 alpha 1) were little or unaffected by vaccination, suggesting tumor regression driven by Th1 inflammation without other global modifications of the TME (Hong et al, 2022). This evidence concerns the gene VEGFC and neoplasm.