The detoxified adenylate cyclase of Bordetella pertussis harboring E7 lost its therapeutic effect against large TC‐1 tumors and required association with CpG adjuvant and anti‐Treg cyclophosphamide treatment to achieve tumor eradication, only occurring in 58% of individuals (Berraondo et al, 2007). This evidence concerns the gene ADCY1 and neoplasm.