Moreover, univariate Cox regression analysis revealed that PE was associated with survival (unadjusted HR = 3.36, 95% CI 2.03–5.55, p < 0.001), as well as pathological type of lung cancer, NSE, white blood cell (WBC) count, and ECOG PS score (all p < 0.05). The gene discussed is ENO2; the disease is lung cancer.