Subsequent multivariate Cox regression analysis further confirmed that PE was an independent prognostic factor (adjusted HR = 2.26, 95% CI 1.25–4.10, p < 0.001), after adjusting for age, sex, pathological type of lung cancer, NSE, WBC count, chemotherapy, antiangiogenesis therapy, immunotherapy, and ECOG PS score, which is consistent with the previous analysis. This evidence concerns the gene ENO2 and lung cancer.