Apigenin and arctiin at a dose of 0–50 μM reduce cell migration, invasion leading to apoptosis and cell death increasing CDK‐Cyclin mediated G2/M phase cell cycle of the G2/M phase mediated by CDK‐Cyclin, generating ROS and the Bax/Bcl‐2 ratio in the invitro technique inin the glioma U87 cell line.166. Here, BAX is linked to central nervous system cancer.