Equol prevents LPS activity, induces TLR4 activation and JNK phosphorylation, upregulates the expression of Bax and cleaved caspase‐3, downregulates the expression of Bcl‐2, and, when administered at a specific dose of 20 μM, increases apoptosis and neuronal death in vitro glioma cell line C6. Here, BCL2 is linked to central nervous system cancer.