Therefore, the purpose of this study was twofold: 1) to explore the potential ability of acute AE to enhance circulating RAGE, resolve skeletal muscle RAGE expression and related inflammatory signaling in lean individuals and individuals with obesity and 2) to examine the effect of obesity on circulating sRAGE, skeletal muscle RAGE expression, alternative splicing, and related inflammatory signaling. The gene discussed is AGER; the disease is obesity disorder.