AGER and obesity due to melanocortin 4 receptor deficiency: However, esRAGE transcripts were also elevated in OB muscle samples and correlated with BMI (ρ = 0.486, P = 0.03) and body fat percentage (ρ = 0.640, P = 0.002) (Supplemental Table S1), suggesting that RAGE gene transcription is elevated and that the ratio of splicing full-length RAGE to esRAGE was not affected by obesity.