Vogel et al. (2010) hypothesized that the reduced viability in mice is associated with undiagnosed congenital heart disease. We and others have also showed that heart looping and heart development is affected by Pkd1l1; however, none of these studies have examined congenital heart disease in these animal models (Field et al., 2011; Kamura et al., 2011). The gene discussed is PKD1L1; the disease is congenital heart disease.