Several points have been made clear: The expression level of HO-1 affects the progress of kidney disease, and the lack or inhibition of HO-1 will worsen the renal structure and function after injury, while the increased expression has a protective effect; Plasma and urine levels of HO-1 can be used as early biomarkers of certain kidney diseases, earlier than changes in proteinuria and serum creatinine; and HO-1 and its effective inducers can alleviate acute and chronic kidney injury and delay the progression of kidney disease by inducing the expression of HO-1. Here, HMOX1 is linked to kidney disorder.