We demonstrated that in the condition of preserved LVEF, lower eGFR, estimated by either by MDRD or CKD-EPI formula, was significantly associated with lower LV e’, greater maximum LAVi, and elevated NT-proBNP, suggesting that abnormal LV structure and diastolic relaxation may be present in subjects with early stages of kidney disease and progress as renal function declines. The gene discussed is NPPB; the disease is kidney disorder.